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Injectable steroids are typically administered into the muscle, not into the vein, to avoid sudden changes in the amount of the drug in the bloodstream.In addition, because estered testosterone is dissolved in oil, intravenous injection has the potential to cause a dangerous embolism (clot) in the bloodstream.It has been suggested that the prevalence of use among high-school students in the U. In order to be sufficiently active when given by mouth, testosterone derivatives are alkylated at the 17α position, e.g. This modification reduces the liver's ability to break down these compounds before they reach the systemic circulation.Testosterone can be administered parenterally, but it has more irregular prolonged absorption time and greater activity in muscle in enanthate, undecanoate, or cypionate ester form.Conditions pertaining to hormonal imbalances such as gynecomastia and testicular size reduction may also be caused by AAS.[citation needed] Ergogenic uses for AAS in sports, racing, and bodybuilding as performance-enhancing drugs are controversial because of their adverse effects and the potential to gain unfair advantage in physical competitions.Their use is referred to as doping and banned by most major sporting bodies.

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Another male-specific side-effect that can occur is testicular atrophy, caused by the suppression of natural testosterone levels, which inhibits production of sperm (most of the mass of the testes is developing sperm).

Injection is the most common method used by individuals administering AAS for non-medical purposes.

The traditional routes of administration do not have differential effects on the efficacy of the drug.

The word anabolic, referring to anabolism, comes from the Greek ἀναβολή anabole, "that which is thrown up, mound." They are one of three types of sex hormone agonists, the others being estrogens like estradiol and progestogens like progesterone.

AAS were synthesized in the 1930s, and are now used therapeutically in medicine to stimulate muscle growth and appetite, induce male puberty and treat chronic wasting conditions, such as cancer and .

Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream.

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